When sinful man thinks he is cleaner than the dirt he was formed from and touches that which is holy this is what happens.
2 Samuel 6:6-11 NASB
But when they came to the threshing floor of Nacon, Uzzah reached out toward the ark of God and took hold of it, for the oxen nearly upset it. And the anger of the L ord burned against Uzzah, and God struck him down there for his irreverence; and he died there by the ark of God. David became angry because of the L ord ‘ s outburst against Uzzah, and that place is called Perez-uzzah to this day. So David was afraid of the L ord that day; and he said, “How can the ark of the L ord come to me?” And David was unwilling to move the ark of the L ord into the city of David with him; but David took it aside to the house of Obed-edom the Gittite. Thus the ark of the L ord remained in the house of Obed-edom the Gittite three months, and the L ord blessed Obed-edom and all his household.